THAP11 Antilichaam

The THAP domain-contining protein 11 (THAP11), also known as Ronin, is an essential factor involved in embryonic stem (ES) cell pluripotency and cell growth (1) . THAP 11 contains a THAP domain, a conserved DNA-binding domain common to many proteins associated with chromatin modification and gene expression silencing, and has striking similarity to the site-specific DNA-binding domain (DBD) of Drosophila P element transposases (2) . THAP11 can also negatively regulate CD44 v6 expression through its interaction with the poly (rC) binding protein PCBP1 (3) .

57215

Q96EK4

NP_065190

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Stem Cell

THAP11 antibody is affinity chromatography purified via peptide column.

Cat. No. 1303 - Human Brain Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (100%)

THAP11 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

THAP11 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

THAP11 antibody is human, mouse and rat reactive.

THAP11

THAP domain containing 11

Homo sapiens

Dejosez M, Krumenacker JS, Zitur LJ, et al. Ronin is essential for embryogenesis and the pluripotency of mouse ES cells. Cell 2008; 133:1162-74.

Roussigne M, Kossida S, Lavigne AC, et al. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. Trends Biochem. Sci. 2003; 28:66-9.

Lian WX, Yin RH, Kong XZ, et al. THAP11, a novel binding protein of PCBP1, negatively regulates CD44 alternative splicing and cell invasion in a human hepatoma cell line. FEBS Lett. 2012; 586:1431-8.

THAP11 Antibody: RONIN, CTG-B43a, CTG-B45d, HRIHFB2206, THAP domain-containing protein 11

ELISA, WB

40354197

Liquid