Thiaminetrifosforzuurester

Thiamine triphosphoric acid ester (TTP), a neuroactive compound, is a triphosphate derivative of the vitamin thiamine. Thiamine triphosphoric acid ester exists in microorganisms, animal organs and plants. Thiamine triphosphoric acid ester is transiently produced in response to amino acid starvation in E. coli, while constitutively producing at a low rate in mammalian cells. Thiamine triphosphoric acid ester can be synthesized by two different enzymes (AK1 in the cytosol and FoF1-ATP synthase in brain mitochondria) . Thiamine triphosphoric acid ester has a basic role in cell metabolism or cell signaling[1][2].

3475-65-8

Thiamine triphosphate

12352005

H302-H315-H319-H335

Endogenous Metabolite

Metabolic Enzyme/Protease

Metabolic Disease; Neurological Disease

O=P(O)(OP(O)(OP([O-])(OCCC1=C(C)[N+](CC2=CN=C(C)N=C2N)=CS1)=O)=O)O

C12H19N4O10P3S

504.29

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

[1]Makarchikov AF, et al. Thiamine triphosphate and thiamine triphosphatase activities: from bacteria to mammals. Cell Mol Life Sci. 2003 Jul;60 (7) :1477-88.|[2]Bettendorff L, et al. Thiamine triphosphate: a ubiquitous molecule in search of a physiological role. Metab Brain Dis. 2014 Dec;29 (4) :1069-82.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W587827/

Natural Products

No Development Reported