Thiethylperazine (standaard)

Thiethylperazine (Standard) is the analytical standard of Thiethylperazine. This product is intended for research and analytical applications. Thiethylperazine, a phenothiazine derivate, is an orally active and potent dopamine D2-receptor and histamine H1-receptor antagonist. Thiethylperazine is also a selective ABCC1activator that reduces amyloid-β (Aβ) load in mice. Thiethylperazine has anti-emetic, antipsychotic and antimicrobial effects[1][2][3].

1420-55-9

12352100

Amyloid-β; Bacterial; Dopamine Receptor; Histamine Receptor; Reference Standards

Anti-infection; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others

Infection; Neurological Disease

CN1CCN(CCCN2C3=C(C=CC=C3)SC4=CC=C(SCC)C=C24)CC1

C22H29N3S2

399.62

[1]Czeizel AE, et al. Case-control study of teratogenic potential of thiethylperazine, an anti-emetic drug. BJOG. 2003 May;110 (5) :497-9.|[2]Krohn M, et al. Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice. J Clin Invest. 2011 Oct;121 (10) :3924-31.|[3]Rahbar M, et al. Enhancement of vancomycin activity by phenothiazines against vancomycin-resistant Enterococcus faecium in vitro. Basic Clin Pharmacol Toxicol. 2010 Aug;107 (2) :676-9.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-B1794R/

Reference Standards