Thioredoxin-interactief eiwit Antilichaam/TXNIP

Thioredoxin-interacting protein is a protein that in humans is encoded by the TXNIP gene. This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of reactive oxygen species and cellular stress. This protein also functions as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. This protein may also function as a tumor suppressor. Alternate splicing results in multiple transcript variants.

Western blot: 0.5-1 µg/mL, Flow cytometry: 1-3ug/million cells, ELISA: 0.1-0.5 µg/mL

Q9H3M7

Human, Mouse, Rat

An E.coli-derived human recombinant protein (amino acids D122-N152) was used as the immunogen for the Thioredoxin-interacting protein antibody.

WB, FACS, ELISA

Antigen affinity purified

Antigen affinity purified

Lyophilized from 1X PBS with 2% Trehalose

This Thioredoxin-interacting protein antibody is available for research use only.

After reconstitution, the Thioredoxin-interacting protein antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

0.5 mg/mL if reconstituted with 0.2ml sterile DI water

Optimal dilution of the Thioredoxin-interacting protein antibody should be determined by the researcher.

Flow cytometry testing of fixed and permeabilized human MCF7 cells with Thioredoxin-interacting protein antibody at 1ug/million cells (blocked with goat sera) ; Red=cells alone, Green=isotype control, Blue= Thioredoxin-interacting protein antibody.