THRB-antilichaam

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH) . Several alternatively spliced transcript variants encoding the same protein have been observed for this gene.

7068

P10828

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human THRB (NP_000452.2) .

Unconjugated

Primary Antibodies

Cell Cycle, Growth Factors, Neuroscience, Signal Transduction, Transcription

Affinity purification

HepG2

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 53kDa

IgG

WB: 1:500 - 1:2000

THRB

U-87MG

Mouse liver

Mouse eye

Rat liver

Rat eye

Thyroid hormone receptor, beta

Homo sapiens

THRB, GRTH, PRTH, THR1, ERBA2, NR1A2, THRB1, THRB2, C-ERBA-2, C-ERBA-BETA

WB

Liquid