THRB Antilichaam - middelste regio : HRP (ARP37995 P050-HRP)

Thyroid hormone receptor, beta

GRTH, PRTH, THR1, ERBA2, NR1A2, THRB1, THRB2, C-ERBA-2, C-ERBA-BETA

7068

P10828

NP_000452

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish

The immunogen is a synthetic peptide directed towards the middle region of human THRB

THRB is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Defects in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH) . Several transcript variants have been observed for this gene, but the full-length nature of only one has been determined so far. The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH) . Several alternatively spliced transcript variants encoding the same protein have been observed for this gene.

NSD1; NCOA1; RANBP9; NCOR1; RXRA; THRB; MMS19; ADAT3; NCOA2; C1D; NCOA3; ATF2; ANP32A; SUMO1; SUMO2; ROBO4; MED21; HMGN3; EIF3I; NRIP1; RXRG; RXRB; CAMK2B; TBL1XR1; NCOR2; HDAC3; SMC1A; XRCC5; TBL1X; PRKDC; LIG3; HSPA4; GPS2; XRCC6; PARP1; LRIF1; SRC; PSM

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

THRB is supported by BioGPS gene expression data to be expressed in 721_B

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 86%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

53kDa

Candau, R., (2008) Am. J. Hum. Genet. 82 (6), 1270-1280

Wet Ice

461

THRB

THRB

Rabbit

Thyroid hormone receptor beta

NM_000461

YQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKV