Thujopsen

Thujopsene is the inhibitor for cytochrome P450, that inhibits CYP2B6, CYP3A4, CYP2C19, CYP2C8, CYP2C9 with IC50s of 1.3, 12.6, 13.6, 29.8, and 44.9 μM, respectively. Thujopsene binds to PKM2, inhibits the metabolism pathway of cancer cell, induces apoptosis in MKN45, thereby exhibiting antitumor efficacy. Thujopsene exhibits anti-termite and antifungal activities through autoxidation[1][2][3].

470-40-6

12352211

H302, H315, H319, H335

Apoptosis; Cytochrome P450; Fungal; Insecticide; Pyruvate Kinase

Anti-infection; Apoptosis; Metabolic Enzyme/Protease; Others

Cancer; Infection

86.31

CC1(C)[C@]23[C@](C3)([H])C(C)=CC[C@]2(C)CCC1

C15H24

204.35

H302, H315, H319, H335

[1]Jeong HU, et al., Inhibitory effects of cedrol, β-cedrene, and thujopsene on cytochrome P450 enzyme activities in human liver microsomes. J Toxicol Environ Health A. 2014;77 (22-24) :1522-32.|[2]Nagata T, et al. Evaporated fraction of thujopsene from Thujopsis dolabrata starves cancer cells via PKM2 Anti-tumor effect of the volatile components of Thujopsis dolabrata[J]. 2023.|[3]Mukai A, et al. Antitermite and antifungal activities of thujopsene natural autoxidation products[J]. European Journal of Wood and Wood Products, 2019, 77: 311-317.

Room Temperature

Store at room temperature 3 years

http://file.medchemexpress.com/batch_PDF/HY-W587878/Thujopsene-SDS-MedChemExpress.pdf

Reference compound1

No Development Reported

CYP2; CYP3