Thymidylaatsynthase (TYMS) Mouse Monoclonal Antibody [Kloon ID: LBI1E12]

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq, Jul 2008]

Carrier-free (BSA/glycerol-free) TYMS mouse monoclonal antibody, clone LBI1E12

HST422; TMS; TS

Homo sapiens thymidylate synthetase (TYMS), transcript variant 1, mRNA.

7298

P04818

Unconjugated

Metabolic pathways, One carbon pool by folate, Pyrimidine metabolism

Metabolic pathways, One carbon pool by folate, Pyrimidine metabolism

WB 1:2000

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

TYMS

https://www.ncbi.nlm.nih.gov/gene/?term=7298

https://www.uniprot.org/uniprot/P04818