Thymine DNA glycosylase (TDG) Mouse Monoclonal Antibody [Kloon ID: LBI3A12]

The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008]

Carrier-free (BSA/glycerol-free) TDG mouse monoclonal antibody, clone LBI3A12

HTDG

Homo sapiens thymine DNA glycosylase (TDG), transcript variant 1, mRNA.

6996

Q13569

Unconjugated

Base excision repair

Base excision repair

IHC 1:150

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

TDG

https://www.ncbi.nlm.nih.gov/gene/?term=6996

https://www.uniprot.org/uniprot/Q13569