TIE2 (fosfo-Tyr992) Antilichaam

The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.

7010

Q02763

NP_000450.2

Human, Mouse

TIE2 (phospho Tyr992) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 992 (E-V-Y (p) -V-K) derived from Human TIE2.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

126 kDa

IgG

The Antibody detects endogenous levels of TIE2 only when phosphorylated at Tyr992.

Western Blot: 1:500~1:1000

TEK

TEK tyrosine kinase, endothelial

Homo sapiens

Schooley K.A., Baum P.R. Oncogene 8:663-670 (1993)

Dunham I. Nature 429:369-374 (2004)

Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases

Angiopoietin-1 receptor, EC=2.7.10.1 Tunica interna endothelial cell kinase Tyrosine-protein kinase receptor TEK Tyrosine-protein kinase receptor TIE-2 hTIE2 p140 TEK CD202b TEK TIE2

WB

218511853

Liquid