TIM-1 Antilichaam

TIM-1 Antibody: The human form of TIM-1 was initially discovered as a membrane glycoprotein through which the hepatitis A virus can gain entry into a cell. It was also identified as kidney injury molecule 1 (Kim-1), a predicted adhesion molecule that is upregulated on the surfaces of kidney epithelia. It is also expressed on T helper 2 (Th2) cells of the immune system, and following the binding of its natural ligand TIM-4, stimulates T cell expansion and cytokine production in response to viral challenge. It has been suggested that hyperactivation of TIM-1 leads to an increased level of Th2 responsiveness and asthma susceptibility, and antibodies to TIM-1 may therefore be a novel approach to treating asthma.

171283

Q5QNS5

Q5QNS5.2

Mouse, Rat

9927

Unconjugated

Primary Antibodies

Relative Expression Validation (Figure 1) : Anti-TIM-1 antibodies (9927) specificity was further verified by TIM-1 relative expression. TIM-1 antibody (9927) detected high expression levels of TIM-1 in the mouse kidney and testis, while showing very low or no expression in the lung, brain and thymus. This pattern aligns with the RNA expression data for these tissues in human, as reported by Human Protein Atlas. (https://www.proteinatlas.org/ENSG00000113249-HAVCR1/tissue) . Relative Expression Validation9927) TIM-1 antibody (9927) detected high expression levels of TIM-1 in the mouse kidney and testis, while showing very low or no expression in the lung, brain and thymus. This pattern aligns with the RNA expression data for these tissues in human, as reported by Human Protein Atlas. (https://www.proteinatlas.org/ENSG00000113249-HAVCR1/tissue

Immunology, Neuroscience, Signal Transduction, Growth Factors

TIM-1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1405 – Mouse Kidney lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Human: (63%) .

TIM-1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TIM-1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

Mouse TIM-1 has 3 isoforms, including isoform a precursor (305aa, 33kD), isoform b precursor (282aa, 31kD) and isoform b (282aa, 31kD) . Rat TIM-1 has only one isoform identified so far (307aa, 34kD) .

HAVCR1

Cat. No. 1416 – Mouse Testis lysate

Cat. No. 1464 – Rat Liver lysate

Hepatitis A virus cellular receptor 1

Mus musculus

Feigelstock et al. J. Virol. 1998; 72:6621-8

Ichimura et al. J. Biol. Chem. 1998; 273:4135-42

Meyers et al. Mol. Med. 2005; 11:362-9

Mayers et al. Nat. Immunol. 2005;6:455-64.

TIM, KIM1, TIM1, HAVCR, KIM-1, TIM-1, TIMD1, TIMD-1, HAVCR-1, Hepatitis A virus cellular receptor 1, Kidney injury molecule 1, HAVcr-1

ELISA, WB

73919878

Liquid