TIRP Antilichaam

TIRP Antibody: TIRP is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) . TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TIRP, along with other molecules such as TRIF, MAL, and MyD88, serves as an adaptor protein that allows for the interaction and activation of the IL-1R-associated kinase (IRAK) family, the subsequent activation of TNF receptor associated factor (TRAF) -6, and ultimately the activation of NF-κ B. Expression of TIRP appears to be essential for TLR4 signalling.

353376

Q86XR7

AAP81748

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Innate Immunity

TIRP Antibody is Ion exchange chromatography purified.

Cat. No. 1324 - Human Kidney Tissue Lysate

1 mg/mL

TIRP Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TIRP antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

TICAM2

Cat. No. 1405 - Mouse Kidney Tissue Lysate

Cat. No. 1465 - Rat Kidney Tissue Lysate

Toll-like receptor adaptor molecule 2

Homo sapiens

O'Neill LAJ, Fitzgerald FA, and Bowie AG. The Toll-IL-1 receptor adaptor family grows to five members. Trends in Imm. 2003;24:286-9.

Vogel SN, Fitzgerald KA, and Fenton MJ. TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. Mol. Interv. 2003;3:466-77.

Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003;21:335-76.

Janeway CA Jr and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002;20:197-216.

TIRP Antibody: TIRP, TRAM, TIRAP3, MyD88-4, TICAM-2, TIRP, TIR domain-containing adapter molecule 2, Putative NF-kappa-B-activating protein 502

ELISA, WB, IHC-P, IF

32435943

Liquid