TJU103
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
TJU103 is a CD4 inhibitor. TJU103 inhibits autoreactive CD4+ T cells by disrupting the function of the CD4 during activation. TJU103 decreases mononuclear cell infiltration in brain and spinal cord tissue of experimental allergic encephalomyelitis (EAE) mice model. TJU103 downregulates Th1 and Th2 cytokine levels in response to proteolipid protein epitope 139-151 (PLPe) and exhibits inhibitory effects both after the appearance of EAE symptoms and upon rechallenge with Ag. TJU103 can be used for autoimmune diseases like EAE and sclerosis (MS) research[1].
10245-44-0
12352005
H302-H315-H319-H335
Transmembrane Glycoprotein
Immunology/Inflammation
Inflammation/Immunology
O=C(C1=CC=NC=C1)N/N=C/C2=CNC3=C2C=CC=C3
C15H12N4O
264.28
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
[1]Edling AE, et al. An organic CD4 inhibitor reduces the clinical and pathological symptoms of acute experimental allergic encephalomyelitis. J Autoimmun. 2002 Mar;18 (2) :169-79.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-W795993/
Reference compound1
No Development Reported
Beschrijving
TJU103 is a CD4 inhibitor. TJU103 inhibits autoreactive CD4+ T cells by disrupting the function of the CD4 during activation. TJU103 decreases mononuclear cell
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