TL1A / TNFSF15-eiwit (rFc-tag)

TL1A, also known as TNFSF15, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is specifically expressed in endothelial cells. TL1A also can be detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon. TL1A is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It mediates activation of NF-kappa-B. It also inhibits vascular endothelial growth and angiogenesis (in vitro) . TL1A promotes activation of caspases and apoptosis. It is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor.

MGC129934 Protein; MGC129935 Protein; TL1 Protein; TL1A Protein; TNLG1B Protein; VEGI Protein; VEGI192A Protein

NP_005109.2

Human

Human

RFc-Tag

See Datasheet send with the product

< 1.0 EU per μg protein as determined by the LAL method.

> 90 % as determined by SDS-PAGE.

Measured by its ability to induce apoptosis of TF1 human erythroleukemic cells. The ED50 for this effect is typically 20-120 ng/mL.

431

Lyophilized

PBS, pH 7.4

See Datasheet

48 kDa

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

HEK 293 cells