TLR-3 Recombinant eiwit

TLR-3 is a single-pass type I receptor that binds to and signals the presence of microbial pathogens and double stranded RNA (dsRNA) viruses. Signaling through TLR-3 can promote the NF-κB pathway to initiate innate and adaptive immune responses to bacterial and viral infections, as well as the p53 pathway to trigger apoptosis in cells infected with dsRNA viruses. TLR-3 belongs to a family of structurally-related toll-like receptors (TLRs) containing an N-terminal domain rich in leucine repeats and a C-terminal intracellular Toll/interleukin (IL) -1 (TIL) domain. TLR-3 is expressed primarily in dendritic cells of the placenta and pancreas where it can reside on both sides of the plasma membrane and in the endosomal compartment of the cells. Recombinant human TLR-3 is 77.0 kDa glycoprotein containing 681 residues which comprise the TLR-3 extracellular domain.

7098

O15455

NP_003256.1

Recombinant Proteins

HEK293 cells

Innate Immunity, Signal Transduction, Other

Room Temp

The lyophilized TLR-3 recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted TLR-3 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing TLR-3 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Toll-like receptor 3

Homo sapiens

CD283, IIAE2, Toll-like receptor 3

Human

4507531

Lyophilized