TLR1 Antilichaam

TLR1 Antibody: Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR1 is co-expressed with TLR2 on myeloid cells of the innate immune systems in lymphoid tissue such as monocytes and dendritic cells where they form heterodimers that can recognize triacylated lipoproteins.

7096

Q15399

CAG38593

Human, Mouse

Unconjugated

Primary Antibodies

Innate Immunity

TLR1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1406 - Mouse Spleen Tissue Lysate

1 mg/mL

TLR1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TLR1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

TLR1

Toll-like receptor 1

Homo sapiens

Vogel SN, Fitzgerald KA, and Fenton MJ. TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. Mol. Interv. 2003; 3:466-77.

Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003; 21:335-76.

Janeway CA Jr. and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002; 20:197-216.

O'Neill LAJ, Fitzgerald FA, and Bowie AG. The Toll-IL-1 receptor adaptor family grows to five members. Trends in Imm. 2003; 24:286-9.

TLR1 Antibody: TIL, CD281, rsc786, TIL. LPRS5, KIAA0012, Toll-like receptor 1, TIL

ELISA, WB, IHC-P, IF

49065550

Liquid