TLR4 Antilichaam - middengebied: HRP (ARP59041 P050-HRP)

Toll-like receptor 4

TOLL, CD284, TLR-4, ARMD10

7099

O00206

NP_612564

Human, Pig

The immunogen is a synthetic peptide directed towards the middle region of human TLR4

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain.

TNFSF9; SRC; SYK; SMAD3; SERTAD1; BTK; TICAM1; HGS; UBC; HSPA4; TICAM2; STK11IP; TIRAP; TRAF3; TRIM69; IRAK4; TBK1; STUB1; TRAF6; PRKCZ; MYD88; IRAK1; HSPA8; RNF216; CNPY4; SIGIRR; MAPK8IP3; NOX4; TOLLIP; LY96; BCL10; RIPK2; IRAK2; TLR5; DEFB4A; TLR1; HSP

HRP: Horseradish Peroxidase

Polyclonal Antibody

IHC, WB

Affinity Purified

0.5 mg/ml

Human: 100%; Pig: 86%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

93kDa

Wet Ice

839

TLR4

TLR4

Rabbit

Toll-like receptor 4

NM_138554

LGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLTN