TLR6 Antilichaam

TLR6 Antibody: Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR6 was first identified as a close homolog of TLR1, sharing 69% sequence identify. Like TLR1, TLR6 can form heterodimers with TLR2, and these TLR6:TLR2 dimers coordinate macrophage activation by Gram-positive bacteria and the yeast cell wall particle zymosan. Activation of these complexes not only initiates pro-inflammatory cascades, but also can lead to apoptotic responses.

10333

Q9Y2C9

NP_006059

Human, Mouse

Unconjugated

Primary Antibodies

Signal Transduction

TLR6 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1224 - Daudi Cell Lysate

1 mg/mL

TLR6 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TLR6 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed: 91 kDa

IgG

This TLR6 antibody is predicted to have no cross-reactivity to other members of the TLR protein family.

TLR6

Cat. No. 17-005 - Jurkat Cell Slide

Toll-like receptor 6

Homo sapiens

Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003; 21:335-76.

Janeway CA Jr. and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002; 20:197-216.

McGettrick AF and O'Neill LAJ. The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction. Mol Imm. 2004; 41:577-82.

Takeuchi O, Kawai T, Sanjo H, et al. TLR6: A novel member of an expanding Toll-like receptor family. Gene 1999; 231:59-65.

TLR6 Antibody: CD286, Toll-like receptor 6

ELISA, WB, ICC

20143971

Liquid