TLR9 Antilichaam

TLR9 Antibody: Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. TLR9 forms a subfamily along with TLR7 and TLR8 that recognize viral RNA and CpG DNA sequences and are localized in intracellular acidic compartments such as the phagolysosome. Unlike other TLRs which act through adaptor molecules such as TOLLIP, TIRAP, TRIF, and MyD88 to activate various kinases and transcription factors to respond to potential infection, TLR9 is strictly dependent on MyD88.

54106

Q9NR96

AAH32713

Human, Mouse

Unconjugated

Primary Antibodies

Signal Transduction, Innate Immunity

TLR9 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1406 - Mouse Spleen Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Pig: (81%), Bovine: (100%), Sheep: (100%)

TLR9 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TLR9 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

TLR9

Toll-like receptor 9

Homo sapiens

Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003; 21:335-76.

Janeway CA Jr. and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002; 20:197-216.

Wagner H. The immunobiology of the TLR9 subfamily. Trends Immunol. 2004; 381-6

Nishiya T and DeFranco AL. Ligand-regulated chimeric receptor approach reveals distinctive subcellular localization and signaling properties of the Toll-like receptors. J. Biol. Chem. 2004; 279:19008-17.

TLR9 Antibody: CD289, Toll-like receptor 9

ELISA, WB, IHC-P, IF

21595773

Liquid