TLX1 Antilichaam

TLX1 Antibody: The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. TLX1, also called homeobox11 (HOX11), as it is located outside of the four mammalian Hox clusters, is a DNA-binding nuclear transcription factor. TLX1 encodes a homeobox-domain containing protein and is containing a glycine and proline-rich amino terminus. TLX1 is required for maintenance of the developing spleen and cell survival. TLX1 is highly expressed in T-cell leukemia and lymphoid neoplasias as a result of translocation. TLX1-deficient mice have no spleen.

3195

P31314

NP_005512

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Stem Cell

TLX1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1406 - Mouse Spleen Tissue Lysate

1 mg/mL

TLX1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TLX1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

Multiple isoforms of TLX1 exist due to alternative splicing events. TLX1 antibody is predicted to not cross-react with other TLX proteins.

TLX1

Cat. No. 10-901 - Human Spleen Tissue Slide

T-cell leukemia homeobox 1

Homo sapiens

Dear TN, Sanchez-Garcia I, and Rabbitts TH, et al. The Hox11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes. Proc. Natl. Acad. Sci. USA 1993; 90:4431-5.

Dube ID, Kamel-Reid S, Yuan CC, et al. A novel human homeobox gene lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translocation t (10;14) . Blood 1991; 78:2996-3003.

Hatano M, Roberts CW, Minden M, et al. Deregulation of a homeobox gene, Hox11, by the t (10;14) in T cell leukemia. Science 1991; 253:79-82.

Roberts CW, Shutter JR, Korsmeyer SJ et al. Hox11 controls the genesis of the spleen. Nature 1994; 368:747-9.

TLX1 Antibody: TCL3, HOX11, TCL3, T-cell leukemia homeobox protein 1, Homeobox protein Hox-11

ELISA, WB, IHC-P

5031757

Liquid