TM4SF1 Antilichaam

TM4SF1 Antibody: TM4SF1 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains and mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. TM4SF1 is a cell surface antigen and is highly expressed in the vascular endothelium of several human cancers. Knockdown experiments of TM4SF1 prevented filopodia formation, inhibited cell mobility, blocked cytokinesis, and inhibited maturation of VEGF-A-induced angiogenesis, suggesting that TM4SF1 may be an attractive target for anti-angiogenesis therapy.

4071

P30408

NP_055035

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Cancer, Cell Cycle

TM4SF1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1302 - Human Lung Tissue Lysate

1 mg/mL

TM4SF1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TM4SF1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

At least three isoforms of TM4SF1 are known to exist; this antibody will recognize only the two largest isoforms. TM4SF1 antibody is predicted to not cross-react with other tetraspanin proteins.

TM4SF1

Cat. No. 10-101 - Human Lung Tissue Slide

Transmembrane 4 L six family member 1

Homo sapiens

Marken JS, Schieven GL, Hellstrom I, et al. Cloning and expression of the tumor-associated antigen L6. Proc. Natl. Acad. Sci. USA 1992; 89:3503-7

Romanska HM and Berditchevski F. Tetraspanins in human epithelial malignancies. J. Pathol. 2011; 223:4-14

Shih SC, Zukauskas A, Li D, et al. The L6 TM4SF1 is critical for endothelial cell function and tumor angiogenesis. Cancer Res. 2009; 69:3272-7.

TM4SF1 Antibody: L6, H-L6, M3S1, TAAL6, Transmembrane 4 L6 family member 1, Membrane component chromosome 3 surface marker 1

ELISA, WB, IHC-P, IF

21265101

Liquid