TMEM107 Antilichaam

Transmembrane protein 107 (TMEM 107) is critical for cilia formation and embryonic patterning (1) . It is a 139 amino acid transmembrane protein encoded by a gene that maps to human chromosome 17 which is associated with two key tumor suppressor genes p53 and BRCA1 (1,2) . TMEM107 is required for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with Gli2 and Gli3 to pattern ventral and intermediate neuronal cell types (1,3) . TMEM107 is also a strong candidate gene for central areolar choroidal dystrophy (CACD) (1-3) .

84314

Q6UX40

NP_115730

Human

Unconjugated

Primary Antibodies

Immunology

TMEM107 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1208 - THP-1 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Mouse: (86%), Rat: (86%)

TMEM107 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TMEM107antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

TMEM107 antibody is human specific. At least two isoforms of TMEM107 are known to exist.

TMEM107

Cat. No. 11-521 - Human Lymphoid Tissue Tissue Slide

Transmembrane protein 107

Homo sapiens

Christopher KJ, Wang B, Kong Y, et al. Forward genetics uncovers transmembrane protein 107 as a novel factor required for ciliogenesis and sonic hedgehog signaling. Dev. Biol. 2012; 368:382-92.

Clark HF, Gurney AL, Abaya E, et al. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res. 2003; 13:2265-70.

Ho KS and Scott MP. Sonic hedgehog in the nervous system: functions, modifications and mechanisms. Curr. Opin. Neurobiol. 2002; 12:57-63.

TMEM107 Antibody : GRVS638, PRO1268, Transmembrane protein 107

ELISA, WB, IHC-P, IF

34101276

Liquid