TMEM16B Antilichaam

TMEM16B Antibody: Calcium-activated chloride channels (CaCC) are present in many cell types and mediate physiological functions such as epithelial secretion, sensory signal transduction, and smooth muscle contraction. Subunits of these CaCC's include the transmembrane proteins TMEM16A and TMEM16B. TMEM16B is predicted to have eight transmembrane domains with both the amino and carboxy termini in the cytoplasm and is expressed in several tissues including olfactory sensory neurons as well as photoreceptors in mammalian retina. Like TMEM16A, TMEM16B is thought to form at least part of CaCC's but has different biophysical characteristics such as voltage dependence and unitary conductance.

57101

Q9NQ90

NP_001265525

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Neuroscience

TMEM16B Antibody is affinity chromatography purified via peptide column.

Cat. No. 1308 - Human Small Intestine Tissue Lysate

1 mg/mL

TMEM16B Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TMEM16B antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

IgG

ANO2

Cat. No. 10-301 - Human Brain Tissue Slide

Anoctamin 2

Homo sapiens

Schroeder BC, Cheng T, Jan YN, et al. Expression cloning of TMEM16A as a calcium-activated chloride channel subunit. Cell2008; 134:1019-29.

Stephan AB, Shum EY, Hirsh S, et al. ANO2 is the cilial calcium-activated chloride channel that may mediate olfactory amplification. Proc. Natl. Acad. Sci.USA 2009; 106:11776-81.

Pifferi S, Dibattista M, and Menini A. TMEM16 induces chloride currents activated by calcium in mammalian cells. Pflugers Arch.2009; 458:1023-38.

Stohr H, Heisig JB, Benz PM, et al. TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals. J. Neurosci.2009; 29:6809-18.

TMEM16B Antibody: C12orf3, TMEM16B, C12orf3, Anoctamin-2, Transmembrane protein 16B

ELISA, WB, IHC-P, IF

209862785

Liquid