TMEM173 Antilichaam - middengebied HRP (ARP48041 P050-HRP)

Transmembrane protein 173

ERIS, MITA, MPYS, SAVI, NET23, STING, hMITA, hSTING, TMEM173, STING-beta

340061

Q86WV6

NP_938023

Human, Pig

The immunogen is a synthetic peptide directed towards the middle region of human TMEM173

TMEM173 acts as a facilitator of innate immune signaling. It is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. TMEM173 may be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons.It also may be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) . TMEM173 mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.

MAVS; TBK1; UBC; TRAF3; IRF3; TOMM70A; TSPAN6; TRIM32; STT3B; TMEM259; YIPF5; HM13; CLPTM1L; MBOAT7; CCDC47; SEC61A1; CNNM3; LTN1; SLC39A14; GLMN; SGPL1; SURF4; RNF5; ABCC1; STT3A; IRAK1; ACSL3; DDOST; NPC1; TMEM173; TRIM56

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Human: 100%; Pig: 83%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

42kDa

Gerhard, D.S., Genome Res. 14 (10B), 2121-2127 (2004)

Wet Ice

379

TMEM173

TMEM173

Rabbit

Transmembrane protein 173

NM_198282

DPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPL