TMEM38A Antilichaam

TMEM38A Antibody: TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes. TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain and localizes to the sarcoplasmic reticulum (SR) in muscle tissues. Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure; the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores. Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.

79041

Q9H6F2

AAH01195

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Signal Transduction

TMEM38A Antibody is affinity chromatography purified via peptide column.

Cat. No. 1467 - Rat Skeletal Muscle Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rabbit: (94%), Bovine: (94%), Chicken: (76%)

TMEM38A Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TMEM38A antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

TMEM38A

Transmembrane protein 38A

Homo sapiens

Yazawa M, Ferrante C, Feng J, et al. TRIC channels are essential for Ca2+ handling in intracellular stores. Nature2007; 448:78-82.

Yamakazi D, Yamakazi T, and Takeshima H. New molecular components supporting ryanodine receptor-mediated Ca (2+) release: roles of junctophilin and TRIC channel in embryonic cardiocytes. Pharmacol. Ther.2009; 121:265-72.

TMEM38A Antibody: TRICA, TRIC-A, Trimeric intracellular cation channel type A, Transmembrane protein 38A

ELISA, WB, IF

12654711

Liquid