TMIGD1 Antilichaam

TMIGD1 (transmembrane and immunoglobulin domain containing 1) is a 262 amino acid single-pass membrane protein that contains two Ig-like C2-type (immunoglobulin-like) domains (1,2) . It is a nonsecreted, glycosylated protein located in the cytoplasm and cell membrane (1) . TMIGD1 might be a possible cell-differentiation marker in the intestine, whose expression is lost during cellular transformation and promote progression of tumorigenesis in the intestinal epithelium (2-4) . TMIGD1 has also been postulated to play a role in cell adhesion (2) .

388364

Q6UXZ0

NP_996663

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Stem Cell

TMIGD1 antibody is affinity chromatography purified via peptide column.

Cat. No. 1464 - Rat Liver Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (72%)

TMIGD1 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TMIGD1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

TMIGD1 antibody is human, mouse and rat reactive. At least two isoforms of TMIGD1 are known to exist; this antibody will detect both isoforms.

TMIGD1

Transmembrane and immunoglobulin domain containing 1

Homo sapiens

Clark HF, Gurney AL, Abaya E, et al. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res. 2003; 13:2265-70.

Fujimoto K, Beauchamp RD, Whitehead RH. Identification and isolation of candidate human colonic clonogenic cells based on cell surface integrin expression. Gastroenterology 2002; 123:1941–8.

Yan J, Jiang J, Lim CA, et al. Blimp-1 regulates cell growth through repression of p53 transcription. Proc. Natl. Acad. Sci. USA 2007; 104:1841-6.

Cattaneo E, Laczko E, Buffoli F, et al. Preinvasive colorectal lesion transcriptomes correlate with endoscopic morphology (polypoid vs. nonpolypoid) . EMBO Mol Med. 2011; 3:334-47.

TMIGD1 Antibody: TMIGD, UNQ9372, TMIGD, UNQ9372/PRO34164, Transmembrane and immunoglobulin domain-containing protein 1

ELISA, WB, IHC-P, IF

45592949

Liquid