TMPO

TMPO (3,3,5,5-Tetramethyl-1-pyrroline 1-oxide) is a spin trap targeting free radicals. TMPO is capable of scavenging superoxide, hydroxyl radicals and inhibits thymocyte apoptosis with EC50 values of 19.1 mM (MPS-induced) to 30.7 mM (Etoposide-induced) for inhibiting DNA fragmentation. TMPO reacts with intracellular free radicals to form stable nitroxide radical products, reducing oxidative stress (e.g., decreasing peroxide levels, maintaining glutathione content) and blocking oxidative events in the apoptotic pathway. TMPO is promising for research of apoptosis in immune cells like thymocytes[1][2].

10135-38-3

3,3,5,5-Tetramethyl-1-pyrroline 1-oxide

12352005

H315-H319

Apoptosis; Reactive Oxygen Species (ROS)

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Inflammation/Immunology

CC1(C)CC(C)(C)[N+](=C1)[O-]

C8H15NO

141.21

P264-P280-P302+P352-P305+P351+P338-P362+P364

[1]Buettner GR, et al. The spin trapping of superoxide with M4PO (3,3,5,5-tetramethylpyrroline-N-oxide) . Free Radic Biol Med. 1990;8 (1) :57-60.|[2]Slater AF, et al. Nitrone spin traps and a nitroxide antioxidant inhibit a common pathway of thymocyte apoptosis. Biochem J. 1995 Mar 15;306 (Pt 3) (Pt 3) :771-8.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W271506/

Reference compound1

No Development Reported