TMS1 (PYCARD) Mouse Monoclonal Antibody [Kloon ID: LBI2A7]

This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD) . The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Carrier-free (BSA/glycerol-free) PYCARD mouse monoclonal antibody, clone LBI2A7

ASC; CARD5; TMS; TMS-1; TMS1

Homo sapiens PYD and CARD domain containing (PYCARD), transcript variant 1, mRNA.

29108

Q9ULZ3

Unconjugated

Cytosolic DNA-sensing pathway, NOD-like receptor signaling pathway

Cytosolic DNA-sensing pathway, NOD-like receptor signaling pathway

WB 1:500~2000, IHC 1:150, FLOW 1:100

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

PYCARD

https://www.ncbi.nlm.nih.gov/gene/?term=29108

https://www.uniprot.org/uniprot/Q9ULZ3