TNF beta Recombinant eiwit

TNF-β is a potent mediator of inflammatory and immune responses. It belongs to the TNF family of ligands and signals through TNFR1 and TNFR2. TNF-β is produced by activated T and B lymphocytes, and has similar activities to TNF-alpha. Like TNF-α , TNF-β is involved in the regulation of various biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. TNF-β is secreted as a soluble polypeptide, but can form heterotrimers with lymphotoxin-β , which effectively anchors the TNF-β to the cell surface. TNF-β is cytotoxic to a wide range of tumor cells. Recombinant human TNF-β is a secreted 171 amino acid protein (18.6 kDa) which forms an active non-disulfide linked homotrimer structure in solution.

4049

P01374

NP_000586.2

Recombinant Proteins

E. coli

Cancer, Immunology, Signal Transduction

Room Temp

The lyophilized TNF beta recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted TNF beta is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing TNF beta recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Lymphotoxin alpha

Homo sapiens

LT, TNFB, TNFSF1, Lymphotoxin-alpha, TNF-beta, LT-alpha

Human

6806893

Lyophilized