TNFAIP1 Antilichaam

TNFAIP1 is a BTB/POZ domain-containing protein that belongs to the KCTD10/BACURD family which mediates POZ-POZ interactions and chromatin modeling (1,2) . The expression of TNFAIP1 is developmentally regulated in a tissue-specific manner and can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells (3) . TNFAIP1 may be involved in DNA repair, DNA synthesis, and cell apoptosis. TNFAIP1 is suggested to play a role in the process of cancer and in the innate immunity against the Hepatitis B virus (4,5) .

7126

Q13829

NP_066960

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Apoptosis, Cancer, Innate Immunity

TNFAIP1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1403 - Mouse Brain Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Chicken: (100%)

TNFAIP1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TNFAIP1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

TNFAIP1 antibody is human, mouse and rat reactive. TNFAIP1 antibody is predicted to not cross-react with other TNFAIP proteins.

TNFAIP1

Tumor necrosis factor, alpha-induced protein 1 (endothelial)

Homo sapiens

Liu M, Sun Z, Zhou A, et al. Functional characterization of the promoter region of human TNFAIP1 gene. Mol. Biol. Rep. 2010; 37:1699-705.

Hu X, Yan F, Wang F, et al. TNFAIP1 interacts with KCTD10 to promote the degradation of KCTD10 proteins and inhibit the transcriptional activities of NF-?B and AP-1. Mol. Biol. Rep. 2012; 39:9911-9.

Zhang CL, Wang C, Yan WJ, et al. Knockdown of TNFAIP1 inhibits growth and induces apoptosis in osteosarcoma cells through inhibition of the nuclear factor-?B pathway. Oncol. Rep. 2014; 32:1149-55.

Kim DM, Chung KS, Choi SJ, et al. RhoB induces apoptosis via direct interaction with TNFAIP1 in HeLa cells. Int. J. Cancer 2009; 125:2520-7.

Tumor necrosis factor, alpha-induced protein 1, BTB/POZ domain-containing protein TNFAIP1, BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2, BACURD2, EDP1

ELISA, WB, IHC-P, IF

10863937

Liquid