TNFRSF17 / BCMA (CD269) Proteïne (ECD, hFc-tag)

Tumor necrosis factor receptor superfamily, member 17 (TNFRSF17), also known as B cell maturation antigen (BCMA) or CD269 antigen, is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13BBAFF), and to lead to NF-kappaB and MAPK8/JNK activation. TNFRSF17/BCMA/CD269 also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. TNFRSF17/BCMA/CD269 is a receptor for TALL-1 and BCMA activates NF-kappaB through a TRAF5-, TRAF6-, NIK-, and IKK-dependent pathway. The identification of TNFRSF17 as a NF-kappaB-activating receptor for TALL-1 suggests molecular targets for drug development against certain immunodeficient or autoimmune diseases. TNFRSF17/BCMA is a target of donor B-cell immunity in patients with myeloma who respond to DLI. Antibody responses to cell-surface BCMA may contribute directly to tumor rejection in vivo.

BCM Protein; BCMA Protein; CD269 Protein; TNFRSF13A Protein

NP_001183.2

Human

Human

HFc-Tag

See Datasheet send with the product

< 1.0 EU per μg of the protein as determined by the LAL method

≥ 95 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.

1. Immobilized Recombinant Human TNFRSF17 / BCMA (CD269) Protein (ECD, Fc tag) at 2 μg/mL (100 μL/well) can bind biotinylated Anti-BCMA Antibody, Human IgG1, the EC50 is 0.5-2 ng/mL. 2. Loaded Recombinant Human APRIL/TNFSF13 Protein, Trimer, Flag-His Tag on HIS1K Biosensor, can bind Recombinant Human BCMA Protein, hFc Tag with an affinity constant of 0.653 nM as determined in BLI assay (Sartorius Octet RED384) .

292

Lyophilized

PBS, pH 7.4

See Datasheet

41 kDa (glycosylated)

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

HEK 293 cells