TNFSF12-eiwit (hFc-tag)

TNFSF12 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is a ligand for the FN14/TWEAKR receptor. TNFSF12 has overlapping signaling functions with TNF, but displays a much wider tissue distribution. It can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. It is also found that TNFSF12 promotes proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. TNFSF12 also is a weak inducer of apoptosis in some cell types and mediates NF-kappa-B activation.

Tnlg4a Protein; TWEAK Protein

NP_001001513.2

Rat

Rat

HFc-Tag

See Datasheet send with the product

< 1.0 EU per μg of the protein as determined by the LAL method

> 90 % as determined by SDS-PAGE

Immobilized Fc-rat TNFSF12 at 10 μg/mL (100 μL/well) can bind biotinylated human Fc-TNFRSF12A. The EC50 of biotinylated human Fc-TNFRSF12A is 0.12-0.28 μg/mL.

405

Lyophilized

PBS, pH 7.4

See Datasheet

49 kDa (glycosylated)

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

HEK 293 cells