TNFSF4 Antilichaam

TNFSF4 Antibody: The tumor necrosis factor superfamily member TNFSF4 is a type II membrane bound, non-covalently linked homotrimeric protein. It is expressed on antigen presenting cells, such as dendritic cells and activated B-cells, and also on other cells such as vascular endothelial cells, mast cells, and natural killer cells. TNFSF4 signals specifically through the TNFRSF4 receptor, is expressed predominantly on CD4+T cells but also on certain activated CD8+T cells. TNFRSF4/TNFSF4 functions as a costimulatory signal, which is required for a productive interaction between antigen presenting cells and their target T-cells. It enhances cell proliferation and survival, and increases expression of RANTES, IL-2, IL-3, and IFNγ . TNFRSF4/TNFSF4 signaling plays an important role in immunotolerance.

7292

P23510

NP_003317

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Immunology

TNFSF4 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1466 - Rat Spleen Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rabbit: (91%)

TNFSF4 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TNFSF4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

20 kDa

IgG

At least two isoforms of TNFSF4 are known to exist; this antibody will detect both isoforms.

TNFSF4

Cat. No. 10-901 - Human Spleen Tissue Slide

Tumor necrosis factor (ligand) superfamily, member 4

Homo sapiens

Arch RH and Thompson CB. 4-1BB and Ox40 are members of a tumor necrosis factor (TNF) -nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB. Mol. Cell Biol.1998; 18:558-65.

OX40-OX40 ligand interaction in T-cell-mediated immunity and immunopathy. Adv. Immunol. 2010; 105:63-98

TNFSF4 Antibody: GP34, CD252, OX4OL, TXGP1, CD134L, OX-40L, Tumor necrosis factor ligand superfamily member 4, Glycoprotein Gp34, OX40L

ELISA, WB, IHC-P, IF

4507603

Liquid