TNNT1 Antilichaam

This gene encodes a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year. Multiple transcript variants encoding different isoforms have been found for this gene.

7138

P13805

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 1-262 of human TNNT1 (NP_001119604.1) .

Unconjugated

Primary Antibodies

Apoptosis, Cell Cycle, Growth Factors, Signal Transduction

Affinity purification

HT-1080

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 33kDa

IgG

TNNT1

A-549

SW480

Troponin T type 1 (skeletal, slow)

Homo sapiens

TNNT1, ANM, MGC104241, TNT, NEM5, STNT, TNTS

WB, IF

Liquid