TOB1 (fosfo Ser164) Antilichaam

This gene encodes a member of the tob/btg1 family of anti-proliferative proteins that have the potential to regulate cell growth. When exogenously expressed, this protein supresses cell growth in tissue culture. The protein undergoes phophorylation by a serine/threonine kinase, 90 kDa ribosomal S6 kinase. Interactions of this protein with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interferes with growth suppression. This protein inhibits T cell proliferation and transcription of cytokines and cyclins. The protein interacts with both mothers against decapentaplegic Drosophila homolog 2 and 4 to enhance their DNA binding activity. This interaction inhibits interleukin 2 transcription in T cells.

10140

P50616

NP_001230806.1

Human, Mouse, Rat

TOB1 (phospho Ser164) antibody was raised against a peptide sequence around phosphorylation site of Serine 164 (A-V-S (p) -P-T) derived from Human TOB1.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

40 kDa

IgG

The antibody detects endogenous levels of TOB1 only when phosphorylated at serine 164.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

TOB1

Transducer of ERBB2, 1

Homo sapiens

Matsuda S., Oncogene 12:705-713 (1996) .

Ebert L., Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.

Kalnine N., Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.

TOB, Transducer of erbB-2 1

WB, IHC

345197216

Liquid