TOP2A Antilichaam

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.

7153

P11388

Human, Mouse

A synthetic peptide of human TOP2A

Unconjugated

Primary Antibodies

Apoptosis, Cancer, Cell Cycle

Affinity purification

Jurkat

Batch dependent

PBS with 0.02% sodium azide, pH7.3.

None

Blue Ice

Store at 4˚ C. Avoid freeze / thaw cycles.

Observed: 200kDa

IgG

TOP2A

K-562

A375

SKOV3

NIH/3T3

Topoisomerase (DNA) II alpha 170kDa

Homo sapiens

TOP2A, TOP2, TP2A

WB, IHC, IF

Liquid