TOP2A (fosfo Thr1343) Antilichaam

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event.

7153

P11388

NP_001058.2

Human

TOP2A (phospho Thr1343) antibody was raised against a peptide sequence around phosphorylation site of threonine1343 (E-K-T (p) -D-D) derived from Human TOP2A.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

190 kDa

IgG

The antibody detects endogenous levels of TOP2A only when phosphorylated at threonine 1343.

Western Blot: 1:500~1:1000

TOP2A

Topoisomerase (DNA) II alpha 170kDa

Homo sapiens

Tsai-Pflugfelder M., Proc. Natl. Acad. Sci. U.S.A. 85:7177-7181 (1988) .

Wasserman R.A., Cancer Res. 53:3591-3596 (1993) .

Lang A.J., Gene 221:255-266 (1998) .

TP2A, TOP2, TOP2A, P11388-1

WB

19913406

Liquid