TOR Antilichaam

TOR Antibody: The mammalian Target of Rapamycin (TOR, also known as mTOR) is an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors. It was initially discovered as a kinase whose ability to stimulate T cell proliferation in response to IL-2 could be inhibited by the immunosuppressive drug rapamycin. Rapamycin inhibits TOR in other cell types resulting in reduced cell growth and reduced rates of cell cycle and cell proliferation. TOR is normally associated with the regulatory proteins RAPTOR and GbetaL. Its downstream targets are thought to be the ribosomal protein S6 kinases and the eukaryotic initiation factor 4E binding proteins (4EBPs) . Regulation of these protein families allows TOR to control protein biosynthesis.

2475

P42345

NP_004949

Human, Mouse

Unconjugated

Primary Antibodies

Signal Transduction, Neuroscience

TOR Antibody is affinity chromatography purified via peptide column.

Cat. No. 1284 - L1210 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rat: (100%)

TOR Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TOR antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

MTOR

Cat. No. 17-204 - L1210 Cell Slide

Mechanistic target of rapamycin

Homo sapiens

Shamji AF, Ngheim P, and Schreiber SL. Integration of growth factor and nutrient signaling: implications for cancer biology. Mol. Cell 2003; 12:271-80.

Sabatini DM, Erdjument-Bromage H, Lui M, et al. RAFT1: a mammalian protein that binds to FKP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell 1994; 78:35-43.

Cardenas ME, Zhu D, and Heitman J. Molecular mechanisms of immunosuppression by cyclosporine, FK506, and rapamycin. Curr. Opin. Nephrol. Hypertens. 1995; 4:472-7.

Fingar DC and Blenis J. Target of rapamycin (TOR) : an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 2004; 23:3151-71.

TOR Antibody: FRAP, FRAP1, FRAP2, RAFT1, RAPT1, FRAP, FK506-binding protein 12-rapamycin complex-associated protein 1, mTOR

ELISA, WB, ICC

4826730

Liquid