Tozasertib (VX-680)
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
639089-54-6
MK-0457
C16078-100mg
Aurora Kinase
Cell Cycle
CC1=CC (=NN1) NC2=CC (=NC (=N2) SC3=CC=C (C=C3) NC (=O) C4CC4) N5CCN (CC5) C
C23H28N8OS
Tozasertib (VX-680) is a pan-Aurora inhibitor, mostly against Aurora A with Kiapp of 0.6 nM in a cell-free assay, less potent towards Aurora B/Aurora C and 100-fold more selective for Aurora A than 55 other kinases. The only exceptions are Fms-related tyrosine kinase-3 (FLT-3) and BCR-ABL tyrosine kinase, which are inhibited by the Tozasertib with both Ki of 30 nM. Tozasertib induces apoptosis and autophagy. Phase 2.
2 years -80 in solvent
Beschrijving
Tozasertib (VX-680) Beschikbaar in 100 mg. Wordt geleverd met droogijs. Bestel eenvoudig online met snelle levering.
Specificaties
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