TP1 Antilichaam

TP1 Antibody: Telomerase is an RNA-dependent DNA polymerase that uses an RNA component to add telomeric repeat sequences at the ends of chromosomes. Besides the RNA component which serves as the template that specifies the telomeric repeat, the telomerase complex contains a reverse transcriptase protein (TRT) and various accessory proteins including the telomerase-associated protein 1 (TP1) . Telomerase activity is low in most somatic cells, causing the gradual shortening of telomeres which can ultimately lead to telomere fusion and cell death. High levels of telomerase activity are widely seen in cancerous cells and while recent experiments have suggested that telomerase may be a viable target in cancer therapy, expression levels of TP1 do not correlate with malignancy. At least two isoforms of TP1 are known to exist.

7011

Q99973

AAC51107

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis

TP1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1305 - Human Kidney Tissue Lysate

1 mg/ml

TP1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TP1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

TEP1

Cat. No. 10-101 - Human Lung Tissue Slide

Telomerase-associated protein 1

Homo sapiens

Greider CW. Telomere length regulation. Annu. Rev. Biochem.1996; 274:92-7.

Cong YS, Wright WE, and Shay JW. Human telomerase and its regulation. Microbiol. Mol. Biol. Rev.2002; 66:407-25.

Harrington L, McPhail T, Mar V, et al. A mammalian telomerase-associated protein. Science1997; 275:973-7.

Wong JMY and Collins K. Telomere maintenance and disease. Lancet2003; 362:983-8.

TP1 Antibody: TP1, TLP1, p240, TROVE1, VAULT2, TP1, Telomerase protein component 1, Telomerase-associated protein 1, Telomerase protein 1

ELISA, WB, IHC-P, IF

1848277

Liquid