TPH2 (fosfo Ser19) Antilichaam

This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.

121278

Q8IWU9

NP_775489.2

Human, Mouse, Rat

TPH2 (phospho Ser19) antibody was raised against a peptide sequence around phosphorylation site of Serine 19 (G-F-S (p) -L-D) derived from Human TPH2.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

56 kDa

IgG

The antibody detects endogenous levels of TPH2 only when phosphorylated at serine 19.

Western Blot: 1:500~1:1000

TPH2

Tryptophan hydroxylase 2

Homo sapiens

Walther D.J., Science 299:76-76 (2003) .

Scherer S.E., Nature 440:346-351 (2006) .

ADHD7, NTPH, TPH2

WB

31795563

Liquid