TPM1 Antilichaam

This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy.

7168

P09493

Human, Mouse, Rat, Zebrafish

Recombinant fusion protein containing a sequence corresponding to amino acids 1-245 of human TPM1 (NP_001018008.1) .

Unconjugated

Primary Antibodies

Cell Cycle, Signal Transduction

Affinity purification

A-549

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 36kDa

IgG

TPM1

BT-474

THP-1

DU145

SW480

MCF7

Tropomyosin 1 (alpha)

Homo sapiens

TPM1, CMH3, TMSA, TPM1-alpha, CMD1Y, LVNC9, C15orf13, HTM-alpha

WB, IHC, IF

Liquid