TPM1 Antilichaam - N-terminalgebied: FITC (ARP41392_T100-FITC)

Tropomyosin 1 (alpha)

CMH3, TMSA, CMD1Y, LVNC9, C15orf13, HEL-S-265, HTM-alpha

7168

P09493

NP_000357

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish

The immunogen is a synthetic peptide directed towards the N terminal region of human TPM1

TPM1 is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction.This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy.

GOLGA2; CAGE1; C1orf216; SYCE1; KXD1; TFPT; MAD1L1; TPM4; TP53; TNNT1; UBC; MDM2; ETFA; FOXK1; KIAA1598; PPP6R3; APPL2; CDC37; MGEA5; STUB1; ABI2; DNAJC7; HSP90B1; PARK2; LRCH3; PAN2; TGFBR1; SPTBN1; ATF2; MDC1; BRCA1; PPP4R2; SRXN1; NUDCD2; RBM15; THOC2

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

IHC, WB

0.5 mg/ml

Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 93%; Zebrafish: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

31kDa

Lin, J.C. (2005) Mol. Cell. Biol. 25 (22), 10111-10121

Wet Ice

284

TPM1

TPM1

Rabbit

Tropomyosin alpha-1 chain

NM_000366

DRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQE