TPO

TPO is a lineage specific growth factor, produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and murine TPO exhibits cross-species reactivity. Recombinant human TPO is a fully biologically active 174 amino acid polypeptide (18.6 kDa), which contains the erythropoietin-like domain of the full length TPO protein.

Thrombopoietin, Megakaryocyte colony-stimulating factor, c-MPL Ligand, MGDF

7066

P40225

NP_000451.1

NM_000460.2

2p25

Human

Human

SPAPPACDLR VLSKLLRDSH VLHSRLSQCP EVHPLPTPVL LPAVDFSLGE WKTQMEETKA QDILGAVTLL LEGVMAARGQ LGPTCLSSLL GQLSGQVRLL LGALQSLLGT QLPPQGRTTA HKDPNAIFLS FQHLLRGKVR FLMLVGGSTL CVRRAPPTTA VPSRTSLVLT LNEL

> 98% by SDS-PAGE

The ED50 as determined by the dose-dependant stimulation of MO7e cells is < 1 ng/ml (1x106 units/mg) .

174

Lyophilized

18.6 kDa

E. coli