TPT1 Antilichaam

TPT1 Antibody: TPT1 (translationally controlled tumor protein 1) is a 23 kDa member of the TCTP family of calcium binding proteins. TPT1 is localized in the cytoplasm and widely expressed and serves as a transcriptional activator, calcium transporter, histamine inducer and antiapoptotic caspase 3 inhibitor. TPT1 is a cytokine-like molecule that causes the release of histamine, IL-4 and IL-13 from basophils as well as the secretion of IL-8 and a calcium response in eosinophils. TPT1 plays a pivotal role in allergic diseases and due to its wide distribution in brain, is thought to be involved in neurodegenerative disorders, such as Alzheimer's disease and Down syndrome.

7178

P13693

NP_003286

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Immunology

TPT1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1303 - Human Brain Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rabbit: (100%), Bovine: (100%), Pig: (100%), Chicken: (74%)

TPT1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TPT1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Predicted: 19 kDa

IgG

TPT1

Tumor protein, translationally-controlled 1

Homo sapiens

MacDonald SM, Rafnar T, Langdon J, et al. Molecular identification of an IgE-dependent histamine-releasing factor. Science 1995; 269:688-90.

MacDonald SM. Human recombinant histamine-releasing factor. Int. Arch. Allergy Immunol. 1997; 113:187-9.

Sanchez JC, Schaller D, Ravier F, et al. Translationally controlled tumor protein: a protein identified in several nontumoral cells including erythrocytes. Electrophoresis 1997; 18:150-5.

Kuna P and Kaplan AP. Relationship of histamine-releasing factors and histamine-releasing inhibitory factors to chemokine group of cytokine. Allergy Asthma Proc. 1996; 17:5-11.

TPT1 Antibody: HRF, p02, p23, TCTP, Translationally-controlled tumor protein, Fortilin

ELISA, WB, IHC-P, IF

4507669

Liquid