TRAF1 Antilichaam

The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV) . EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for this gene.

7185

Q13077

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 217-416 of human TRAF1 (NP_005649.1) .

Unconjugated

Primary Antibodies

Apoptosis, Cancer, Cell Cycle, Growth Factors, Signal Transduction

Affinity purification

SGC-7901

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 50kDa

IgG

WB: 1:500 - 1:2000

TRAF1

A-431

U-937

Jurkat

Mouse spleen

Rat thymus

TNF receptor-associated factor 1

Homo sapiens

TRAF1, TNF receptor-associated factor 1, EBI6, MGC:10353, Epstein-Bar virus-induced protein 6

WB

Liquid