TRAF6 Antilichaam

TRAF6 Antibody: Signals from the IL-1 receptor (IL-1R) /Toll-like receptor (TLR) and TNF receptor (TNFR) superfamilies are critical for regulating the function of antigen-presenting cells. Signals transduced by these molecules lead to increased expression and activation of transcription factors such as NF-κ B. TNF receptor-associated factor 6 (TRAF6) is unique in that it is a signaling adapter molecule common to both families. TRAF6 is important in cytokine production, dendritic cell (DC) maturation, and the T cell stimulatory capacity of DCs in response to TLR and CD40 ligands. It can be activated in the IL-1R/TLR signaling pathway by IL-1 receptor-associated kinase 1 (IRAK-1) or by other TLR adaptor molecules such as TRIF. Also, it has been shown that TRAF6 can interact directly with TNFR family members CD40 and RANK.

7189

Q9Y4K3

NP_004611

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Signal Transduction

TRAF6 Antibody is Ion exchange chromatography purified.

Cat. No. 1216 - PC-3 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (86%), Pig: (92%)

TRAF6 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TRAF6 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

TRAF6

Cat. No. 1204 - K562 Cell Lysate

Cat. No. 17-004 - K-562 Cell Slide

TNF receptor-associated factor 6

Homo sapiens

Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003; 21:335-76.

Wu H. Assembly of post-receptor signaling complexes for the tumor necrosis factor superfamily. Adv. Protein Chem. 2004; 68:225-79.

Wajant H and Scheurich P. Analogies between Drosophila and mammalian TRAF pathways. Prog. Mol. Subcell. Biol. 2004; 34:47-72.

Kobayashi T, Walsh PT, Walsh MC, et al. TRAF6 is a critical factor for dendritic cell maturation and development. Immunity 2003; 19:353-63.

TRAF6 Antibody: RNF85, MGC:3310, RNF85, E3 ubiquitin-protein ligase TRAF6

ELISA, WB, ICC, IF

4759254

Liquid