Trail Antilichaam

Trail Antibody: Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. TRAIL (TNF-related apoptosis-inducing ligand) is a type II membrane protein and expressed in a variety of human tissues (1,2) . The death domain containing receptors DR4 and DR5 have been identified as the receptor for TRAIL (3-6) . Like TNF and Fas ligand, TRAIL induces apoptosis and NF-κ B activation in many tissues and cells.

8743

P50591

NP_003801

Human

Unconjugated

Primary Antibodies

Apoptosis, Cancer

Trail Antibody is affinity chromatography purified via peptide column.

Cat. No. 1201 - HeLa Cell Lysate

1 mg/ml

Predicted species reactivity based on immunogen sequence: Mouse: (82%)

Trail Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Trail antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

TNFSF10

Cat. No. 1303 - Human Brain Tissue Lysate

Cat. No. 10-301 - Human Brain Tissue Slide

Tumor necrosis factor (ligand) superfamily, member 10

Homo sapiens

Wiley SR, Schooley K, Smolak PJ, et al. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 1995; 3:673-82.

Pitti RM, Marsters SA, Ruppert S, et al. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J. Biol. Chem. 1996; 271:12687-90.

Pan G, O'Rourke K, Chinnaiyan AM, et al. The receptor for the cytotoxic ligand TRAIL. Science; 1997; 276:111-3.

Schneider P, Thome M, Burns K, et al. TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-κ B. Immunity 1997; 7:831-6.

Trail Antibody: TL2, APO2L, CD253, TRAIL, Apo-2L, Tumor necrosis factor ligand superfamily member 10, Apo-2 ligand

ELISA, WB, IHC-P, IF

4507593

Liquid