TRAIL (TNFSF10) Mouse Monoclonal Antibody [Kloon ID: LBI12E12]

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Carrier-free (BSA/glycerol-free) TNFSF10 mouse monoclonal antibody, clone LBI12E12

Apo-2L; APO2L; CD253; TL2; TRAIL

Homo sapiens TNF superfamily member 10 (TNFSF10), transcript variant 1, mRNA.

8743

P50591

Unconjugated

Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicity

Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicity

WB 1:500

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome, Transmembrane

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

TNFSF10

https://www.ncbi.nlm.nih.gov/gene/?term=8743

https://www.uniprot.org/uniprot/P50591