TRAP-14-amide

TRAP-14 amide, a proteinase activated receptor (PAR) -activating peptide, is a PAR agonist with an EC50 of 24 μM. TRAP-14 amide significantly induces platelet aggregation through ADP- and MMP-2-dependent pathways with Aspirin -insensitivity. TRAP-14 amide also effectively increases glycoprotein (GP) Ib and GPIIb/IIIa surface expression and ADP release[1].

141923-36-6

12352209

Integrin; MMP; Protease Activated Receptor (PAR)

Cytoskeleton; GPCR/G Protein; Metabolic Enzyme/Protease

Neuroscience-Neuromodulation

Cardiovascular Disease

OC[C@H](N)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(N2[C@@H](CCC2)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N3[C@@H](CCC3)C(N[C@H](C(N)=O)CC4=CC=CC=C4)=O)=O)=O)CC5=CC=C(C=C5)O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

C81H119N21O22

1738.94

[1]Chung AW, et al. Mechanisms of action of proteinase-activated receptor agonists on human platelets. Br J Pharmacol. 2002 Mar;135 (5) :1123-32. |[2]Chung AW, et al. Mechanisms of action of proteinase-activated receptor agonists on human platelets. Br J Pharmacol. 2002 Mar;135 (5) :1123-32.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P5764/

Peptides

No Development Reported

MMP-2; αIIbβ3